Aluminium lithium hydride → 3-[(4-methylpiperazin-1-yl)methyl]-1H-indole

HRID 254191Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 254191
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10]([N:12]2[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]2)=O)=[CH:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[CH3:18][N:15]1[CH2:16][CH2:17][N:12]([CH2:10][C:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[NH:1][CH:2]=2)[CH2:13][CH2:14]1

Komponenten

4

Edukt 2

HCID 21226445Aluminium lithium hydrideHCID 21854014HCID 21854014, Verbindung

Produkt 1

HCID 2275843-[(4-methylpiperazin-1-yl)methyl]-1H-indole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

(1H-Indol-3-yl)-(4-methylpiperazin-1-yl)methanone (2.44 g, 0.01 moles) in THF was treated with cooled and stirred suspension of Lithium aluminum hydride (g, 0.011 moles in THF slowly over the period of 2 to 5 hours, the reaction mixture was heated to reflux for 2-4 hours, after the completion of reaction, the reaction mixture was poured on to the ice and the compound was extracted in ethyl acetate. The residue obtained was purified by flash chromatography (silica gel, EtOAc/Hexanes, 2/8) to afford the compound, which was identified by IR, NMR and mass spectral analyses as the title compound.

Aufarbeitung

  1. temperaturewith cooled
  2. temperaturethe reaction mixture was heated
  3. temperatureto reflux for 2-4 hours
  4. customafter the completion of reaction
  5. extractionthe compound was extracted in ethyl acetate
  6. customThe residue obtained
  7. customwas purified by flash chromatography (silica gel, EtOAc/Hexanes, 2/8)
  8. customto afford the compound, which

Quellen und Nachweise

ORD-Eintrag
ord-db9fb9c74c724df1a2c7e0c692015dc6
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07875605B2

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