4-Bromo-1,1,1-trifluorobutane → 5-tert-butyl-3-(4,4,4-trifluorobutyl)thiazol-2(3H)-imine hydrobromide

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A mixture of the product of Example 74A (0.25 g, 1.6 mmol) and 1-bromo-4,4,4-trifluorobutane (336 mg, 1.8 mmol) was warmed to 85° C. and was stirred for 16 hours. The mixture was cooled to ambient temperature and the title compound (0.35 g, 63% yield) was isolated via filtration. MS (DCI/NH3) m/z 267 (M+H)+.

Herkunft & Nachweise