HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrogen Peroxide → (4R,4aS,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrogen Peroxide | HCID 784 | — |
| Edukt | Peracetic Acid | HCID 6585 | — |
| Edukt | Oxycodone | HCID 5284603 | — |
| Edukt | Codeinone | HCID 5459910 | — |
| Edukt | (4R,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline;2,3,4-trihydroxy-4-oxobutanoate | HCID 131728625 | — |
| Lösungsmittel | Formic Acid | HCID 284 | — |
| Lösungsmittel | Isopropanol | HCID 3776 | — |
| Produkt | (4R,4aS,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one | HCID 5359420 | — |
Reaktionsschritte
Oxycodone has also been prepared from thebaine bitartrate and codeinone ethyldienol ether by oxidation with hydrogen peroxide in formic acid and isopropanol, followed by catalytic hydrogenation5. Oxycodone has also been prepared by the oxidation with peracetic acid of codeinone dienol silylether in organic solvents to give 14-hydroxycodeinone, followed by catalytic hydrogenation in acetic acid solution15.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07875719B2 |
| Quelldatensatz | uspto-grants-2011_01 |
| ORD ID | ord-4a9bcdf3242041dfa8552b1c331e322b |
| Quellennotiz | uspto-grants-2011_01 |