Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 2-(Bromomethyl)tetrahydro-2H-pyran | HCID 141917 | — |
| Edukt | 2-Amino-5-methylthiazole | HCID 351770 | — |
| Produkt | Ammonia | HCID 222 | — |
| Produkt | Ammonium Hydroxide | HCID 14923 | — |
| Produkt | 5-Methyl-3-(tetrahydro-pyran-2-ylmethyl)-3H-thiazol-2-ylideneamine | HCID 66859610 | — |
Reaktionsschritte
A mixture of 2-amino-5-methylthiazole (1.2 g, 11 mmol) and 2-(bromomethyl)tetrahydro-2H-pyran (1.5 mL, 12 mmol) was warmed to 85° C. and stirred for 18 hours. The mixture was cooled to ambient temperature and purified via flash column chromatography (SiO2, 10% methanol in ethyl acetate then 9:1:0.1 CH2Cl2:methanol:NH4OH) to afford the title compound MS (DCI/NH3) m/z 213 (M+H)+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US07875639B2 |
|---|
| Quelldatensatz | uspto-grants-2011_01 |
|---|
| ORD ID | ord-364c5e65b6104f5e9e835916c10da7f5 |
|---|
| Quellennotiz | uspto-grants-2011_01 |
|---|
