2-(4-((Tert-butoxycarbonyl)amino)piperidin-1-yl)ethyl methanesulfonate → HCID 178453928, Verbindung
Reaktionsgleichung
[OH:1][CH2:2][CH2:3][C@H:4]1[CH2:9][CH2:8][C@H:7]([NH:10][C:11](=[O:17])[O:12][C:13]([CH3:16])([CH3:15])[CH3:14])[CH2:6][CH2:5]1.[CH3:18][S:19](OCCN1CCC(NC(OC(C)(C)C)=O)CC1)(=[O:21])=[O:20]>>[CH3:18][S:19]([O:1][CH2:2][CH2:3][C@H:4]1[CH2:5][CH2:6][C@H:7]([NH:10][C:11]([O:12][C:13]([CH3:14])([CH3:16])[CH3:15])=[O:17])[CH2:8][CH2:9]1)(=[O:21])=[O:20]Komponenten
3
Versuchsvorschrift
Commercially available tert-butyl [trans-4-(2-hydroxyethyl)cyclohexyl]carbamate (500 mg, 2.05 mmol) was reacted according to the procedure described for Intermediate 6 to give the product as a white solid (yield 92%).
Quellen und Nachweise
- ORD-Eintrag
- ord-b4710da4790544b1852e44b3dda957bd
- Quelldatensatz
- uspto-grants-2011_01