HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Citric Acid → Benzyl 2-methylaziridine-1-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Citric Acid | HCID 311 | — |
| Edukt | 2-Methylaziridine | HCID 6377 | — |
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | Benzyl chloroformate | HCID 10387 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | Benzyl 2-methylaziridine-1-carboxylate | HCID 21895246 | — |
Reaktionsschritte
2-Methyl aziridine is dissolved in CH2Cl2 and triethylamine under argon at 0° C. Benzylchloroformate is added and the contents of the flask are at room temperature overnight. The mixture is poured into 10% citric acid and is extracted with CHCl3. The organic layer is washed with dilute aqueous NaHCO3 and dried over MgSO4. The solution is evaporated to yield N-Cbz-2-methyl aziridine.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04698231 |
| Quelldatensatz | uspto-grants-1987_10 |
| ORD ID | ord-1a4e7089217245829b297700e2f626b8 |
| Quellennotiz | uspto-grants-1987_10 |