Isobutyl chloroformate → HCID 178453651, Verbindung

HRID 25554

Reaktionsgleichung

Cl.[Br:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([NH:14][CH3:15])[CH2:10][CH2:9]1.Cl[C:17]([O:19][CH2:20][CH:21]([CH3:23])[CH3:22])=[O:18]>>[CH2:20]([O:19][C:17](=[O:18])[N:14]([C@H:11]1[CH2:12][CH2:13][C@H:8]([O:7][CH2:6][CH2:5][CH2:4][CH2:3][Br:2])[CH2:9][CH2:10]1)[CH3:15])[CH:21]([CH3:23])[CH3:22]

Komponenten

Edukt 2

HCID 62365Isobutyl chloroformate

HCID 178484847HCID 178484847, Verbindung

Produkt 1

HCID 178453651HCID 178453651, Verbindung

Versuchsvorschrift

In analogy to example 11.4, trans-[4-(4-Bromo-butoxy)-cyclohexyl]-methyl-amine hydrochloride and isobutyl chloroformate (with 2.1 eq N,N-diisopropylethylamine) were reacted to yield trans-[4-(4-Bromo-butoxy)-cyclohexyl]-methyl-carbamic acid isobutyl ester which was used directly in the next steps see Example 12.45-12.54.

Quellen und Nachweise

ORD-Eintrag: ord-b3d31884ab3b488b93786e6af807f0d5
Quelldatensatz: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06858651B2

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