Phosphorus oxychloride → HCID 20184101, Verbindung

HRID 255700Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 255700
[CH3:1][N:2]([CH3:31])[CH2:3][CH2:4][CH2:5][N:6]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:7]1[C:12]([NH:13][C:14](=O)[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[N+:21]([O-:23])=[O:22])=[CH:11][CH:10]=[CH:9][N:8]=1.P(Cl)(Cl)([Cl:34])=O>>[ClH:34].[CH3:1][N:2]([CH3:31])[CH2:3][CH2:4][CH2:5][N:6]1[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[C:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[N+:21]([O-:23])=[O:22])=[N:13][C:12]2[CH:11]=[CH:10][CH:9]=[N:8][C:7]1=2

Komponenten

3

Edukt 2

HCID 24813Phosphorus oxychlorideHCID 13986493HCID 13986493, Verbindung

Produkt 1

HCID 20184101HCID 20184101, Verbindung

Versuchsvorschrift

Following the procedure of Example 51, N-[2-[[3-(dimethylamino)propyl]phenylamino]-3-pyridinyl]-2-nitrobenzamide was cyclized to the free base of title compound with phosphorus oxychloride and thereafter converted to the hydrochloride by reacting with ethereal hydrogen chloride. Recrystallization from isopropyl alcohol, the yellow solid melted at 239°240° C.

Quellen und Nachweise

ORD-Eintrag
ord-050b83e8ccc645c68cc89a2353c38786
Quelldatensatz
uspto-grants-1987_10
Patentnummer
US04698430

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