Dodecane, 1-isocyanato- → N-Octadecyl-N-(D-glucopyranosyl)-N'-dodecylurea

HRID 255874

Reaktionsgleichung

Reaktionsgleichung von HRID 255874
[CH2:1]([NH:19][CH:20]1[O:28][C@H:27]([CH2:29][OH:30])[C@@H:25]([OH:26])[C@H:23]([OH:24])[C@H:21]1[OH:22])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[CH2:31]([N:43]=[C:44]=[O:45])[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42]>O1CCCC1.C(O)C>[CH2:1]([N:19]([CH:20]1[O:28][C@H:27]([CH2:29][OH:30])[C@@H:25]([OH:26])[C@H:23]([OH:24])[C@H:21]1[OH:22])[C:44]([NH:43][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])=[O:45])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

Komponenten

5

Edukt 2

HCID 77873Dodecane, 1-isocyanato-HCID 13361749N-octadecylglucopyranosylamine

Produkt 1

HCID 13517874N-Octadecyl-N-(D-glucopyranosyl)-N'-dodecylurea

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

9 g of the compound from Example 1 are suspended in 160 ml of tetrahydrofuran and 40 ml of ethanol. 4.3 g of dodecyl isocyanate, dissolved in 20 ml of tetrahydrofuran, are added dropwise to this suspension in the course of 20 minutes. When the reaction has ended, the mixture is evaporated in vacuo and the resulting syrup is purified by column chromatography (mobile phase methylene chloride/methanol, 15:1)

Aufarbeitung

  1. additionare added dropwise to this suspension in the course of 20 minutes
  2. customthe mixture is evaporated in vacuo
  3. customthe resulting syrup is purified by column chromatography (mobile phase methylene chloride/methanol, 15:1)

Quellen und Nachweise

ORD-Eintrag
ord-991551d7b76645ff896dda6c416665b0
Quelldatensatz
uspto-grants-1987_10
Patentnummer
US04699899

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