3-Buten-1-amine → HCID 178457207, Verbindung
Reaktionsgleichung
F[C:2](F)(F)C(O)=O.[CH3:8][NH:9][C@H:10]1[CH2:15][CH2:14][C@H:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]OS(C)(=O)=O)[CH2:12][CH2:11]1.Cl[C:27]([O:29][C:30]1[CH:35]=[CH:34][C:33]([F:36])=[C:32]([F:37])[CH:31]=1)=[O:28].[CH2:38]([CH2:41][NH2:42])[CH:39]=C>>[F:37][C:32]1[CH:31]=[C:30]([O:29][C:27](=[O:28])[N:9]([C@H:10]2[CH2:11][CH2:12][C@H:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][N:42]([CH2:41][CH:38]=[CH2:39])[CH3:2])[CH2:14][CH2:15]2)[CH3:8])[CH:35]=[CH:34][C:33]=1[F:36]Komponenten
4
Versuchsvorschrift
In analogy to examples 29.10 and 29.11, trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester-Trifluoroacetic acid salt and 3,4-difluoro-phenyl chloroformate were reacted, followed by treatment with N-allylmethylamine to yield trans-{4-[5-(Allyl-methyl-amino)-pentyl]-cyclohexyl}-methyl-carbamic acid 3,4-difluoro-phenyl ester, MS: 409 (MH+).