Dimethyl acetylenedicarboxylate → Dimethyl 3-thienylaminobutenedioate
Reaktionsgleichung
[NH2:1][C:2]1[CH:6]=[CH:5][S:4][CH:3]=1.[CH3:7][O:8][C:9]([C:11]#[C:12][C:13]([O:15][CH3:16])=[O:14])=[O:10]>CO>[S:4]1[CH:5]=[CH:6][C:2]([NH:1][C:11](=[CH:12][C:13]([O:15][CH3:16])=[O:14])[C:9]([O:8][CH3:7])=[O:10])=[CH:3]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
3-Aminothiophene is redissolved in methanol (500 mL) cooled in an ice bath and dimethylacetylenedicarboxylate (80 g; 0.50 mol) is added dropwise. The mixture is stirred at room temperature for 15 hours and 30 minutes, the methanol removed under reduced pressure and 1,2-dichloroethane is added. This solvent is also evaporated off to give dimethyl 3-thienylaminobutenedioate as an oil.
Aufarbeitung
- temperaturecooled in an ice bath
- customthe methanol removed under reduced pressure and 1,2-dichloroethane
- additionis added
- customThis solvent is also evaporated off
Quellen und Nachweise
- ORD-Eintrag
- ord-c2f9da94f0164059b226ff8a22801101
- Quelldatensatz
- uspto-grants-1987_10
- Patentnummer
- US04701208
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