2H-1-Benzopyran-2-one, 7-(3-chloropropoxy)- → HCID 14014462, Verbindung

HRID 256150

Reaktionsgleichung

Reaktionsgleichung von HRID 256150
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:16]=[CH:15][C:9]2[CH:10]=[CH:11][C:12](=[O:14])[O:13][C:8]=2[CH:7]=1.[S:17]1[CH:21]=[CH:20][CH:19]=[C:18]1[CH:22]1[CH:27]=[CH:26][NH:25][CH2:24][CH2:23]1>CN(C=O)C>[S:17]1[CH:21]=[CH:20][CH:19]=[C:18]1[C:22]1[CH2:27][CH2:26][N:25]([CH2:2][CH2:3][CH2:4][O:5][C:6]2[CH:16]=[CH:15][C:9]3[CH:10]=[CH:11][C:12](=[O:14])[O:13][C:8]=3[CH:7]=2)[CH2:24][CH:23]=1

Komponenten

4

Edukt 2

HCID 19006662H-1-Benzopyran-2-one, 7-(3-chloropropoxy)-HCID 201641434-(2-Thienyl)tetrahydropyridine

Produkt 1

HCID 14014462HCID 14014462, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A 2.9 g (0.012 mole) sample of 7-(3-chloropropoxy)-2H-1-benzopyran-2-one as prepared in Example 1 above, 2 g (0.012 mole) 4-(2-thienyl)tetrahydropyridine, and 5 g NaHCo3 in 80 ml DMF is stirred at 80°-90° C. for seven hours at room temperature overnight then filtered and evaporated in vacuo. The residue in methylene dichloride is washed with NaHCO3, dried (MgSO4) and evaporated in vacuo. 7-[3-[3,6-Dihydro-4-(2-thienyl)-1(2H)-pyridinyl]propoxy]-2H-1-benzopyran-2-one as 4.3 g of dark oil was obtained. The oil was dissolved in 20 ml of 2-propanol and treated with 3 ml of 20% 2-propanolic hydrogen chloride solution to give 2.4 g of the monhydrochloride salt, mp 235-7° C.

Aufarbeitung

  1. filtrationthen filtered
  2. customevaporated in vacuo
  3. washThe residue in methylene dichloride is washed with NaHCO3
  4. dry with materialdried (MgSO4)
  5. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-cfd26132e9584b4cae356c5919dc06f0
Quelldatensatz
uspto-grants-1987_10
Patentnummer
US04701456

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