Phosphorus tribromide → 2,2,5,5-Tetramethyl-1-cyclopentylmethylbromide

HRID 256255

Reaktionsgleichung

Reaktionsgleichung von HRID 256255
[CH3:1][C:2]1([CH3:11])[CH2:6][CH2:5][C:4]([CH3:8])([CH3:7])[CH:3]1[CH2:9]O.P(Br)(Br)[Br:13]>C1C=CC=CC=1>[CH3:1][C:2]1([CH3:11])[CH2:6][CH2:5][C:4]([CH3:8])([CH3:7])[CH:3]1[CH2:9][Br:13]

Komponenten

4

Edukt 2

HCID 24614Phosphorus tribromideHCID 13629260(2,2,5,5-Tetramethylcyclopentyl)methanol

Produkt 1

HCID 136292612,2,5,5-Tetramethyl-1-cyclopentylmethylbromide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel2×

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

2,2,5,5-Tetramethyl-1-cyclopentylmethanol is dissolved in benzene and stirred at 0° C. under argon. A solution of phosphorus tribromide in benzene is added and the mixture is stirred for 2 hours and then heated to 60° C. for 4 hours. The mixture is cooled, poured into ice and extracted with ether. The organic layer is washed with saturated NaHCO3, dried over MgSO4 and evaporated to yield 2,2,5,5-Tetramethyl-1-cyclopentylmethyl bromide.

Aufarbeitung

  1. stirringthe mixture is stirred for 2 hours
  2. temperatureheated to 60° C. for 4 hours
  3. temperatureThe mixture is cooled
  4. additionpoured into ice
  5. extractionextracted with ether
  6. washThe organic layer is washed with saturated NaHCO3
  7. dry with materialdried over MgSO4
  8. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-b24f7ef350984c38b2b104737856de51
Quelldatensatz
uspto-grants-1987_10
Patentnummer
US04701552

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