Trifluoroacetic acid → HCID 178457217, Verbindung

HRID 25626

Reaktionsgleichung

Reaktionsgleichung von HRID 25626
[CH3:1][NH:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([CH2:9][CH2:10][CH2:11][CH2:12]OS(C)(=O)=O)[CH2:5][CH2:4]1.FC(F)(F)C(O)=O.[F:25][C:26]([F:38])([F:37])[C:27]1[CH:32]=[CH:31][C:30]([S:33](Cl)(=[O:35])=[O:34])=[CH:29][CH:28]=1.[CH2:39]([NH:42][CH3:43])[CH:40]=[CH2:41]>>[CH2:39]([N:42]([CH3:43])[CH2:12][CH2:11][CH2:10][CH2:9][C@H:6]1[CH2:5][CH2:4][C@H:3]([N:2]([CH3:1])[S:33]([C:30]2[CH:31]=[CH:32][C:27]([C:26]([F:38])([F:37])[F:25])=[CH:28][CH:29]=2)(=[O:35])=[O:34])[CH2:8][CH2:7]1)[CH:40]=[CH2:41]

Komponenten

5

Edukt 4

HCID 6422Trifluoroacetic acidHCID 69391N-MethylallylamineHCID 27773994-(Trifluoromethyl)benzenesulfonyl chlorideHCID 178484800HCID 178484800, Verbindung

Produkt 1

HCID 178457217HCID 178457217, Verbindung

Versuchsvorschrift

In analogy to examples 31.5 and 31.6, trans-Methanesulfonic acid 4-(4-methylamino-cyclohexyl)-butyl ester.trifluoro-acetic acid and and 4-trifluoromethyl-phenyl-sulfonylchloride were reacted, followed by treatment with N-allyl-N-methylamine to give trans-N-{4-[4-(Allyl-methyl-amino)-butyl]-cyclohexyl}-N-methyl-4-trifluoromethyl-benzenesulfonamide, MS: 447 (MH+).

Quellen und Nachweise

ORD-Eintrag
ord-9b7c69e8bf6440608ef6f7ab93b482bf
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06858651B2

Verknüpfte Notizen

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