Trifluoroacetic acid → HCID 178457218, Verbindung

HRID 25630

Reaktionsgleichung

Reaktionsgleichung von HRID 25630
[CH3:1][NH:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([CH2:9][CH2:10][CH2:11][CH2:12]OS(C)(=O)=O)[CH2:5][CH2:4]1.FC(F)(F)C(O)=O.[F:25][C:26]([F:38])([F:37])[C:27]1[CH:32]=[CH:31][C:30]([S:33](Cl)(=[O:35])=[O:34])=[CH:29][CH:28]=1.[CH3:39][NH:40][CH2:41][CH2:42][CH3:43]>>[CH3:1][N:2]([C@H:3]1[CH2:4][CH2:5][C@H:6]([CH2:9][CH2:10][CH2:11][CH2:12][N:40]([CH3:39])[CH2:41][CH2:42][CH3:43])[CH2:7][CH2:8]1)[S:33]([C:30]1[CH:31]=[CH:32][C:27]([C:26]([F:38])([F:37])[F:25])=[CH:28][CH:29]=1)(=[O:35])=[O:34]

Komponenten

5

Edukt 4

HCID 6422Trifluoroacetic acidHCID 12315N-MethylpropylamineHCID 27773994-(Trifluoromethyl)benzenesulfonyl chlorideHCID 178484800HCID 178484800, Verbindung

Produkt 1

HCID 178457218HCID 178457218, Verbindung

Versuchsvorschrift

In analogy to examples 31.5 and 31.6, trans-Methanesulfonic acid 4-(4-methylamino-cyclohexyl)-butyl ester.trifluoro-acetic acid and 4-trifluoromethyl-phenyl-sulfonylchloride were reacted, followed by treatment with methyl-propyl-amine to give trans-N-Methyl-N-{4-[4-(methyl-propyl-amino)-butyl]-cyclohexyl}-4-trifluoromethyl-benzenesulfonamide, MS: 449 (MH+).

Quellen und Nachweise

ORD-Eintrag
ord-87ca8e65c17446c9b2bcadba7e18d7f8
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06858651B2

Verknüpfte Notizen

Wird geladen…