HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Anthranilic Acid → N-Phenylanthranilic Acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Anthranilic Acid | HCID 227 | — |
| Edukt | 2-Bromo-4-methyl-1-nitrobenzene | HCID 8167038 | — |
| Produkt | N-Phenylanthranilic Acid | HCID 4386 | — |
Reaktionsschritte
As shown in Scheme 7, coupling of 3-bromo-4-nitrotoluene with 2-amino-benzoic acid via an Ullmann reaction yields an N-phenyl-anthranilic acid. After protection of the acid with 2-amino-2-methyl-1-propanol, oxidation affords the corresponding aldehyde. Addition of vinyl magnesium bromide and deprotection provides the N-phenyl-anthranilic acid containing a latent Michael acceptor. ##STR15##
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05258296 |
| Quelldatensatz | uspto-grants-1993_11 |
| ORD ID | ord-b14e64830dbb4528bce163796757ab04 |
| Quellennotiz | uspto-grants-1993_11 |