Monobasic potassium phosphate → Ribavirin

HRID 256512

Reaktionsgleichung

Reaktionsgleichung von HRID 256512
[NH:1]1C=CN=N1.[C@@H:6]1([N:15]2C3N=C[N:21]=[C:19]([OH:20])[C:18]=3[N:17]=[CH:16]2)[O:14][C@H:11]([CH2:12][OH:13])[C@@H:9]([OH:10])[C@H:7]1[OH:8].P([O-])(O)(O)=O.[K+]>>[CH:16]1[N:15]([C@@H:6]2[O:14][C@H:11]([CH2:12][OH:13])[C@@H:9]([OH:10])[C@H:7]2[OH:8])[N:1]=[C:18]([C:19]([NH2:21])=[O:20])[N:17]=1

Komponenten

4

Edukt 3

HCID 516951Monobasic potassium phosphateHCID 178418936HCID 178418936, VerbindungHCID 178521066(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-hydroxypurin-9-yl)oxolane-3,4-diol

Produkt 1

HCID 37542Ribavirin

Versuchsvorschrift

By using a substrate solution (pH 6.0) containing 40 mM triazole as the base donor, 60 mM inosine as the saccharide residue donor and 40 mM potassium dihydrogenphosphate, reactions were carried out in the same manner as in Example 1 at respective reaction temperature (40° to 70° C.) for 24 hours to produce ribavirin. The results are shown in Table 8.

Quellen und Nachweise

ORD-Eintrag
ord-ad34d5e319f442798901411e2fa06cde
Quelldatensatz
uspto-grants-1993_11
Patentnummer
US05258301

Verknüpfte Notizen

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