Aniline → HCID 15022346, Verbindung

HRID 256521Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 256521
[Cl:1][C:2]1[C:3]([C:7](Cl)=[O:8])=[CH:4][S:5][CH:6]=1.[NH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O1CCOCC1.N1C=CC=CC=1>[Cl:1][C:2]1[C:3]([C:7]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:8])=[CH:4][S:5][CH:6]=1

Komponenten

5

Edukt 2

HCID 6115AnilineHCID 129147964-Chlorothiophene-3-carbonyl chloride

Produkt 1

HCID 15022346HCID 15022346, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1049PyridineLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

At room temperature, a solution of 4-chlorothiophene-3-carboxylic chloride (13.5 g, 0.075 mol) in 30 ml of dioxane is dripped into a solution of aniline (7.7 g, 0.083 mol) in pyridine (160 ml). The mixture is stirred for 12 hours at room temperature and concentrated to dryness, and the residue is taken up in dichloromethane. The organic phase is extracted with aqueous citric acid solution, sodium bicarbonate solution and water, dried and concentrated to dryness. Yield: 16.7 g, 94%; m.p. 119°-121° C.

Aufarbeitung

  1. customAt room temperature
  2. concentrationconcentrated to dryness
  3. extractionThe organic phase is extracted with aqueous citric acid solution, sodium bicarbonate solution and water
  4. customdried
  5. concentrationconcentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-4bf6fee78d27453bbfd45471e4bf980e
Quelldatensatz
uspto-grants-1993_11
Patentnummer
US05258357

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