HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Isopropanol → Nilvadipine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Isopropanol | HCID 3776 | — |
| Edukt | Phosphorus pentachloride | HCID 24819 | — |
| Edukt | 6-Cyano-5-methoxycarbonyl-2-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid | HCID 15388766 | — |
| Produkt | Nilvadipine | HCID 4494 | 97,6% |
Reaktionsschritte
Methyl (-)-5-carboxy-2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate (4.47 g) is reacted with phosphorus pentachloride (3.62 g) and isopropyl alcohol (2.5 g) in the same manner as in Example 7 to provide 5-isopropyl 3-methyl (-)-2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (4.9 g).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05258393 |
| Quelldatensatz | uspto-grants-1993_11 |
| ORD ID | ord-e90cb37427224c40bfdf5480d8f2d9c9 |
| Quellennotiz | uspto-grants-1993_11 |