Hydrochloric Acid → [(1S,2S)-2-hydroxy-1-(3-oxo-propylcarbamoyl)-propyl]-carbamic acid benzyl ester

Beteiligte Stoffe

Reaktionsschritte

By using an analogous procedure to that described for Reference Example 14, [(1S,2S)-1-(3,3-diethoxy-propylcarbamoyl)-2-hydroxy-propyl]-carbamic acid benzyl ester (2 g, 5.24 mmol, obtained from Reference Example 17) in tetrahydrofuran (10 ml) was reacted with 0.5 N hydrochloric acid (10 ml) for 30 minutes at room temperature, to provide [(1S,2S)-2-hydroxy-1-(3-oxo-propylcarbamoyl)-propyl]-carbamic acid benzyl ester (1.56 g, 97%) as a white solid.

Herkunft & Nachweise