Thiazolidinedione → 5-(4-[2-(N-Methyl-N-(2-benzothiazolyl)amino)ethoxy]benzylidene)-2,4-thiazolidinedione

HRID 257183

Reaktionsgleichung

Reaktionsgleichung von HRID 257183
[CH3:1][N:2]([CH2:12][CH2:13][O:14][C:15]1[CH:22]=[CH:21][C:18]([CH:19]=O)=[CH:17][CH:16]=1)[C:3]1[S:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1.[S:23]1[CH2:27][C:26](=[O:28])[NH:25][C:24]1=[O:29].C([O-])(=O)C.[NH2+]1CCCCC1>C1(C)C=CC=CC=1>[CH3:1][N:2]([CH2:12][CH2:13][O:14][C:15]1[CH:22]=[CH:21][C:18]([CH:19]=[C:27]2[S:23][C:24](=[O:29])[NH:25][C:26]2=[O:28])=[CH:17][CH:16]=1)[C:3]1[S:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1

Komponenten

5

Edukt 3

HCID 5437ThiazolidinedioneHCID 3014295Piperidinium acetateHCID 104032434-[2-(N-Methyl-N-(2-benzothiazolyl)amino)ethoxy]benzaldehyde

Produkt 1

HCID 540927945-(4-[2-(N-Methyl-N-(2-benzothiazolyl)amino)ethoxy]benzylidene)-2,4-thiazolidinedione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A solution of 4-[2-(N-methyl-N-(2-benzothiazolyl)amino) ethoxy]benzaldehyde (1.9 g) and 2,4-thiazolidinedione (0.8 g) in toluene (100 ml) containing a catalytic quantity of piperidinium acetate was boiled under reflux in a Dean and Stark apparatus for 2 hours. The mixture was cooled and filtered and the filtered solid was dried to give the title compound (mp 219° C.).

Aufarbeitung

  1. temperatureunder reflux in a Dean and Stark apparatus for 2 hours
  2. temperatureThe mixture was cooled
  3. filtrationfiltered
  4. customthe filtered solid was dried

Quellen und Nachweise

ORD-Eintrag
ord-f65b4ae3793d4719b6a15cbb50a421e4
Quelldatensatz
uspto-grants-1993_11
Patentnummer
US05260445

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