Ammonia → 4-Amino-3-nitropyridine

HRID 257422

Reaktionsgleichung

Reaktionsgleichung von HRID 257422
[N+:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1Cl)([O-:3])=[O:2].C([O-])(=O)C.[NH4+:15].N>>[N+:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[NH2:15])([O-:3])=[O:2]

Komponenten

4

Edukt 3

HCID 222AmmoniaHCID 517165Ammonium AcetateHCID 27357814-Chloro-3-nitropyridine

Produkt 1

HCID 5488034-Amino-3-nitropyridineAusbeute 59 %

Reaktionsbedingungen

Temperatur
135 °C

Versuchsvorschrift

Five grams (31.5 mmol) of 3-nitro-4-chloropyridine was mixed with 26 g of ammonium acetate, and the mixture was heated at 130-140° C. for 3 hours. The mixture was allowed to cool, and then adjusted to pH 10 with concentrated aqueous ammonia. The precipitated powder was collected by filtration to obtain 2.6 g of the intended yield: 59%).

Aufarbeitung

  1. temperatureto cool
  2. filtrationThe precipitated powder was collected by filtration
  3. customto obtain 2.6 g of the intended yield: 59%)

Quellen und Nachweise

ORD-Eintrag
ord-346aaf12786f4e2591f295f5d73eca29
Quelldatensatz
uspto-grants-1993_11
Patentnummer
US05262415

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