Sulfuric Acid → 4'-Chloro-2-hydroxymethylbenzhydrol

HRID 257764

Reaktionsgleichung

Reaktionsgleichung von HRID 257764
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=2[C:10](O)=[O:11])=[O:7])=[CH:4][CH:3]=1.S(=O)(=O)(O)O>CO>[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([CH:6]([C:8]2[C:9]([CH2:10][OH:11])=[CH:13][CH:14]=[CH:15][CH:16]=2)[OH:7])=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 1118Sulfuric AcidHCID 665642-(4'-Chlorobenzoyl)benzoic acid

Produkt 1

HCID 197815594'-Chloro-2-hydroxymethylbenzhydrol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 55 g (0.3M) of 2-(4-chlorobenzoyl) benzoic acid, 5 ml of concentrated sulphuric acid and 500 ml of methanol was heated under reflux for 3 hours. The mixture was evaporated and the residue was taken up in dichloromethane washed with water then aqueous sodium bicarbonate. The dichloromethane was dried and evaporated. The residue was then reduced with lithium aluminium hydride in an analogous manner to that described in Example X1 to give the title compound.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hours
  3. customThe mixture was evaporated
  4. washwashed with water
  5. dry with materialThe dichloromethane was dried
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-dff5d578cf57474aa66ef86101b5313c
Quelldatensatz
uspto-grants-1993_11
Patentnummer
US05264436

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