Hydrochloric Acid → HCID 19092324, Verbindung

HRID 257767Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 257767
[NH2:1][C:2]1[CH:10]=[C:9]([S:11](=[O:14])(=[O:13])[NH2:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].Cl[C:16]([O:18][CH2:19][CH3:20])=[O:17].Cl>[OH-].[Na+]>[CH2:19]([O:18][C:16]([NH:1][C:2]1[CH:10]=[C:9]([S:11](=[O:14])(=[O:13])[NH2:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5])=[O:17])[CH3:20]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 10928Ethyl chloroformateHCID 190923252-Amino-4-sulfamoylbenzoic acid

Produkt 1

HCID 19092324HCID 19092324, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel2×

Versuchsvorschrift

To a solution of 2-amino-4-sulfamoylbenzoic acid (1.32 g) in 2N sodium hydroxide (6 ml) was added dropwise ethyl chloroformate (1.9 ml) and 2N sodium hydroxide on an ice bath. After stirring for 3 hours, the reaction mixture was acidified with 1N hydrochloric acid, extracted with ethyl acetate. Combined organic extracts were washed in turn with water and brine, dried over magnesium sulfate and evaporated to give an amorphous of 2-ethoxycarbonylamino-4-sulfamoylbenzoic acid (1.99 g).

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. washCombined organic extracts were washed in turn with water and brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-5572a17979674af897811a7f66d172a3
Quelldatensatz
uspto-grants-1993_11
Patentnummer
US05264438

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