2-Phenylethanethiol → 6-(2-Fluorophenyl)-2,2-dimethyl-4-phenethylsulfanylmethyl-1,2-dihydroquinoline

HRID 25798

Reaktionsgleichung

Reaktionsgleichung von HRID 25798
[CH3:1][C:2]1([CH3:21])[CH:11]=[C:10]([CH3:12])[C:9]2[C:4](=[CH:5][CH:6]=[C:7](OS(C(F)(F)F)(=O)=O)[CH:8]=2)[NH:3]1.[F:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1B(O)O.[C:32]1([CH2:38][CH2:39][SH:40])[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[F:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[NH:3][C:2]([CH3:1])([CH3:21])[CH:11]=[C:10]2[CH2:12][S:40][CH2:39][CH2:38][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

Komponenten

4

Edukt 3

HCID 781262-PhenylethanethiolHCID 27343542-Fluorophenylboronic acidHCID 20760320Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester

Produkt 1

HCID 99785186-(2-Fluorophenyl)-2,2-dimethyl-4-phenethylsulfanylmethyl-1,2-dihydroquinoline

Versuchsvorschrift

Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester was coupled with 2-fluorophenyl boronic acid. Bromination and coupling reaction with 2-phenylethanethiol gave 72 mg of the title compound.

Quellen und Nachweise

ORD-Eintrag
ord-f7f311fc6d8f4915bfb77b0b353c7d6e
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06858627B2

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