Urea → 4-[2-(Dimethylamino)ethyl]-6,7-dihydro-4-methyl-2-phenyl-4H-pyrano[4,3-d]thiazole

HRID 258584

Reaktionsgleichung

Reaktionsgleichung von HRID 258584
NC(N)=O.[C:5]1([C:11]2[S:12][CH:13]=[C:14]([CH2:16][CH2:17][OH:18])[N:15]=2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[CH3:19][N:20]([CH2:22][CH2:23][C:24](=O)[CH3:25])[CH3:21]>>[CH3:19][N:20]([CH3:21])[CH2:22][CH2:23][C:24]1([CH3:25])[C:13]2[S:12][C:11]([C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=3)=[N:15][C:14]=2[CH2:16][CH2:17][O:18]1

Komponenten

4

Edukt 3

HCID 1176UreaHCID 5469134-(Dimethylamino)butan-2-oneHCID 106083152-Phenyl-4-(beta-hydroxyethyl)thiazole

Produkt 1

HCID 124290164-[2-(Dimethylamino)ethyl]-6,7-dihydro-4-methyl-2-phenyl-4H-pyrano[4,3-d]thiazole

Versuchsvorschrift

By following the procedure of Example 2(a) but using as starting material in Example 2(a) an appropriate starting material of formula II, for example, those described in Examples 2 to 14 and an appropriate aminoketone of formula III in which R2 and n are as described above and A is CH2NR4R5 wherein R4 and R5 are as described above, the amino compounds of formula I listed in Examples 31 to 46 are obtained. For example, according to the present procedure 2-phenyl-4-(β-hydroxyethyl)thiazole condenses with 1-(N,N-dimethylamino)-3-butanone to give the title compound, identical to the amine described in Example 31.

Aufarbeitung

  1. customare obtained

Quellen und Nachweise

ORD-Eintrag
ord-6d090cda82b94c9da739068a5876079f
Quelldatensatz
uspto-grants-1977_07
Patentnummer
US04033977

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