Sodium Carbonate → 2-[3-Bis(2-hydroxyethyl)aminopropyl]amino-quinoline

HRID 258815

Reaktionsgleichung

Reaktionsgleichung von HRID 258815
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[OH:12][CH2:13][CH2:14][N:15]([CH2:19][CH2:20][CH2:21][NH2:22])[CH2:16][CH2:17][OH:18].C(=O)([O-])[O-].[Na+].[Na+]>C(O)(C)C>[OH:18][CH2:17][CH2:16][N:15]([CH2:14][CH2:13][OH:12])[CH2:19][CH2:20][CH2:21][NH:22][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Komponenten

5

Edukt 3

HCID 10340Sodium CarbonateHCID 119282-ChloroquinolineHCID 21088(3-Aminopropyl)diethanolamine

Produkt 1

HCID 214246762-[3-Bis(2-hydroxyethyl)aminopropyl]amino-quinoline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

A mixture of 5.05 g. of 2-chloroquinoline, 5.5 g. of bis(2-hydroxyethyl)aminopropylamine and 3.0 g. of sodium carbonate is heated in 20 ml. of refluxing isopropanol for 24 hours. The reaction mixture is then filtered, solvent removed in vacuo and the residue chromatographed over silica gel to obtain an oil of 2-[3-bis(2-hydroxyethyl)aminopropyl]amino-quinoline.

Aufarbeitung

  1. additionA mixture of 5.05 g
  2. filtrationThe reaction mixture is then filtered
  3. customsolvent removed in vacuo
  4. customthe residue chromatographed over silica gel

Quellen und Nachweise

ORD-Eintrag
ord-03178fbcc19d4bcd8274cb500c301743
Quelldatensatz
uspto-grants-1977_07
Patentnummer
US04035367

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