Hydrochloric Acid → Ethyl p-(2-thenoyl)hydratropate

HRID 258888

Reaktionsgleichung

Reaktionsgleichung von HRID 258888
[C:1]1([C:6]([C:8]2[CH:18]=[CH:17][C:11]([CH:12]([CH3:16])[C:13]([OH:15])=[O:14])=[CH:10][CH:9]=2)=[O:7])[S:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH2:20](O)[CH3:21]>>[C:1]1([C:6]([C:8]2[CH:18]=[CH:17][C:11]([CH:12]([CH3:16])[C:13]([O:15][CH2:20][CH3:21])=[O:14])=[CH:10][CH:9]=2)=[O:7])[S:5][CH:4]=[CH:3][CH:2]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 5359Suprofen

Produkt 1

HCID 12232951Ethyl p-(2-thenoyl)hydratropate

Versuchsvorschrift

A mixture of 5.2 parts of p-(2-thenoyl)hydratropic acid, 40 parts of absolute denatured ethanol and 0.5 parts of hydrochloric acid solution is stirred and refluxed for 24 hours. The reaction mixture is evaporated and the residue is taken up in ether. The ethereal solution is shaken with alkaline water, separated and shaken twice with water. The ether phase is dried, filtered and evaporated, yielding ethyl p-(2-thenoyl)hydratropate, also named ethyl p-(2-thenoyl)-α-methyl-phenylacetate, as a residue.

Aufarbeitung

  1. temperaturerefluxed for 24 hours
  2. customThe reaction mixture is evaporated
  3. stirringThe ethereal solution is shaken with alkaline water
  4. customseparated
  5. stirringshaken twice with water
  6. dry with materialThe ether phase is dried
  7. filtrationfiltered
  8. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-925f1d235b844c00a8f0250c8471af8f
Quelldatensatz
uspto-grants-1977_07
Patentnummer
US04035376

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