Suprofen → p-(2-Thenoyl)hydratropoyl chloride

HRID 258913

Reaktionsgleichung

Reaktionsgleichung von HRID 258913
[C:1]1([C:6]([C:8]2[CH:18]=[CH:17][C:11]([CH:12]([CH3:16])[C:13](O)=[O:14])=[CH:10][CH:9]=2)=[O:7])[S:5][CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:21])=O>C1C=CC=CC=1>[C:1]1([C:6]([C:8]2[CH:18]=[CH:17][C:11]([CH:12]([CH3:16])[C:13]([Cl:21])=[O:14])=[CH:10][CH:9]=2)=[O:7])[S:5][CH:4]=[CH:3][CH:2]=1

Komponenten

4

Edukt 2

HCID 5359SuprofenHCID 24386Thionyl Chloride

Produkt 1

HCID 11747905p-(2-Thenoyl)hydratropoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

A mixture of 5.2 parts of p-(2-thenoyl)hydratropic acid, 4.8 parts of thionyl chloride and 32 parts of anhydrous benzene is stirred and refluxed for 3h. 30. The reaction mixture is evaporated and the residue is evaporated once more from benzene, yielding p-(2-thenoyl)hydratropoyl chloride as a residue.

Aufarbeitung

  1. temperaturerefluxed for 3h
  2. customThe reaction mixture is evaporated
  3. customthe residue is evaporated once more from benzene

Quellen und Nachweise

ORD-Eintrag
ord-6b9439048f53451e9dbe69fab35877a6
Quelldatensatz
uspto-grants-1977_07
Patentnummer
US04035376

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