2-(1H-Pyrrol-1-Yl)Phenol → 8-chloro-4-methyl-4H-pyrrolo-[2,1-c][1,4]benzoxazine-4-carboxylic acid ethyl ester

Reaktionsgleichung

O[C:2]1C=CC=C[C:3]=1N1C=CC=C1.ClC1C=CC(O)=C(N2C=CC=C2)C=1.[Cl:26][C:27]1[CH:28]=[CH:29][C:30]2[O:35][C:34]([CH3:39])([C:36]([OH:38])=[O:37])[C:33]3=[CH:40][CH:41]=[CH:42][N:32]3[C:31]=2[CH:43]=1>>[CH2:2]([O:37][C:36]([C:34]1([CH3:39])[C:33]2=[CH:40][CH:41]=[CH:42][N:32]2[C:31]2[CH:43]=[C:27]([Cl:26])[CH:28]=[CH:29][C:30]=2[O:35]1)=[O:38])[CH3:3]

Komponenten

Edukt 3

HCID 7123342-(1H-Pyrrol-1-Yl)Phenol

HCID 10058445Phenol, 4-chloro-2-(1H-pyrrol-1-yl)-

HCID 123406338-chloro-4-methyl-4H-pyrrolo[2,1-c][1,4]benzoxazine-4-carboxylic acid

Produkt 1

HCID 123406308-chloro-4-methyl-4H-pyrrolo-[2,1-c][1,4]benzoxazine-4-carboxylic acid ethyl ester

Versuchsvorschrift

In the same manner but replacing N-(2-hydroxyphenyl)-pyrrole with an equivalent amount of N-(5-chloro-2-hydroxyphenyl)-pyrrole, 8-chloro-4-methyl-4H-pyrrolo[2,1-c][1,4]benzoxazine-4-carboxylic acid, m.p. 153° - 154° C (dec), νmaxCHCl3 1,725, 1,510, 1,330cm-1, is obtained via the intermediate ester, 8-chloro-4-methyl-4H-pyrrolo-[2,1-c][1,4]benzoxazine-4-carboxylic acid ethyl ester, νmaxCHCl3 1,735 cm-1.