Dimethylamine → 2-hydroxymethyl-5-nitro-N,N-dimethylbenzamide

HRID 259100

Reaktionsgleichung

Reaktionsgleichung von HRID 259100
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][O:9][C:10]2=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH3:14][NH:15][CH3:16]>C(O)C>[OH:9][CH2:8][C:7]1[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:13][C:12]=1[C:10]([N:15]([CH3:16])[CH3:14])=[O:11]

Komponenten

4

Edukt 2

HCID 674DimethylamineHCID 2235846-Nitrophthalide

Produkt 1

HCID 214230322-hydroxymethyl-5-nitro-N,N-dimethylbenzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a stirred solution of 6-nitrophthalide (2 g.) in ethanol (120 ml.) at room temperature was added dimethylamine (in ethanol 33.3% solution: 50 ml.). After stirring for 5 hours the solvent was evaporated off. The resulting gum was dissolved in ethyl acetate. On addition of petrol 60° - 80° a white solid crystallised out.

Aufarbeitung

  1. customwas evaporated off
  2. dissolutionThe resulting gum was dissolved in ethyl acetate
  3. additionOn addition of petrol 60° - 80° a white solid
  4. customcrystallised out

Quellen und Nachweise

ORD-Eintrag
ord-629edec6f3314e72a6d0267038f5bf6e
Quelldatensatz
uspto-grants-1977_07
Patentnummer
US04036829

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