Dimethylamine → 1-(Dimethylamino)-1-octen-3-one
Reaktionsgleichung
Cl[CH:2]=[CH:3][C:4](=[O:10])[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[CH3:11][NH:12][CH3:13]>>[CH3:11][N:12]([CH3:13])[CH:2]=[CH:3][C:4](=[O:10])[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]Komponenten
3
Versuchsvorschrift
A solution of dimethylamine (560 ml, 40% aqueous) is cooled to 5° C. 1-Chloro-1-octen-3-one (192 g) is added and the mixture stirred at room temperature for 20 min. The solution is then saturated with potassium carbonate and extracted with ether. The organic layer is washed 3 × with sat. sodium chloride solution, dried over sodium sulfate, concentrated and distilled to give the title compound, b.p. 94°-96° C./0.2mm.
Aufarbeitung
- extractionsaturated with potassium carbonate and extracted with ether
- washThe organic layer is washed 3 × with sat. sodium chloride solution
- dry with materialdried over sodium sulfate
- concentrationconcentrated
- distillationdistilled
Quellen und Nachweise
- ORD-Eintrag
- ord-da35dbdcd7f34d7eb2f0ca7e02ca73e6
- Quelldatensatz
- uspto-grants-1977_07
- Patentnummer
- US04036856
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