1-Dodecanethiol → 1-(n-Dodecylthio)-3-isopropoxy-2-propanol

HRID 259267

Reaktionsgleichung

Reaktionsgleichung von HRID 259267
[CH:1]([O:4][CH2:5][CH:6]1[O:8][CH2:7]1)([CH3:3])[CH3:2].[H-].[Na+].[CH3:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][SH:23]>O1CCCC1>[CH2:22]([S:23][CH2:7][CH:6]([OH:8])[CH2:5][O:4][CH:1]([CH3:2])[CH3:3])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH3:11]

Komponenten

5

Edukt 3

HCID 81951-DodecanethiolHCID 199202-((1-Methylethoxy)methyl)oxiraneHCID 24758Sodium hydride

Produkt 1

HCID 214239641-(n-Dodecylthio)-3-isopropoxy-2-propanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

2,3-Epoxypropyl isopropyl ether (1.16 g.) in several ml. of dry tetrahydrofuran is added to a stirred suspension formed by the addition of 50 mg. of sodium hydride (56% dispersion in mineral oil) to 2.2 g. 8. of n-dodecylthiol in 50 ml. tetrahydrofuran. The mixture is then stirred at 60° C. After approximately 4 hours the solvent is removed from the reaction mixture and 20 ml. of water is added to the residue. The resultant aqueous mixture is extracted with ether and the ether extracts washed with water, dried over magnesium sulfate and evaporated to yield 1-(n-dodecylthio)-3-isopropoxy-2-propanol.

Aufarbeitung

  1. customformed by the addition of 50 mg
  2. customAfter approximately 4 hours the solvent is removed from the reaction mixture and 20 ml
  3. additionof water is added to the residue
  4. extractionThe resultant aqueous mixture is extracted with ether
  5. washthe ether extracts washed with water
  6. dry with materialdried over magnesium sulfate
  7. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-1f4109b6444941dcb8d0392730d445b1
Quelldatensatz
uspto-grants-1977_07
Patentnummer
US04036974

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