Potassium Hydroxide → 4-Ethoxy-2-methyl-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid

HRID 259408Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 259408
Cl.[CH2:2]([O:4][C:5]1[C:6]2[C:7](=[N:16][N:17]([CH3:19])[CH:18]=2)[N:8]=[CH:9][C:10]=1[C:11]([O:13]CC)=[O:12])[CH3:3].[OH-].[K+]>C(O)C>[CH2:2]([O:4][C:5]1[C:6]2[C:7](=[N:16][N:17]([CH3:19])[CH:18]=2)[N:8]=[CH:9][C:10]=1[C:11]([OH:13])=[O:12])[CH3:3]

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 92019408HCID 92019408, Verbindung

Produkt 1

HCID 214217464-Ethoxy-2-methyl-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

28.5 g. of 4-ethoxy-2 -methyl-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester, hydrochloride from Example 2 and 15 g. of potassium hydroxide are refluxed in 100 ml. of ethanol for 10 hours. The solvent is then distilled off and the residue is dissolved in 20 ml. of water. Acetic acid is added and a precipitate of 16 g. of 4-ethoxy-2-methyl-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid; m.p. 222°-225° (DMF); is obtained.

Aufarbeitung

  1. distillationThe solvent is then distilled off
  2. dissolutionthe residue is dissolved in 20 ml
  3. additionAcetic acid is added
  4. customis obtained

Quellen und Nachweise

ORD-Eintrag
ord-6a3dd96a877940e3b5f88e5709f88c0d
Quelldatensatz
uspto-grants-1977_07
Patentnummer
US04038283

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