Acetaldehyde → 1-Benzhydrylaminoethane phosphonous acid

HRID 25982Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 25982
[CH:1](=O)[CH3:2].[PH2:4]([O-:6])=[O:5].[CH:7]([NH3+:20])([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>O1CCOCC1>[CH:7]([NH:20][CH:1]([P:4]([OH:6])[OH:5])[CH3:2])([C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Komponenten

4

Edukt 2

HCID 177AcetaldehydeHCID 178527021HCID 178527021, Verbindung

Produkt 1

HCID 213258901-Benzhydrylaminoethane phosphonous acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

0.5 Parts of freshly distilled acetaldehyde was added to a suspension of 2.5 parts of benzhydrylammonium hypophosphite in 10 parts of dioxan at room temperature and the mixture stirred for 15 minutes. The mixture was then heated slowly to 50° when solution occurred and a flocculent precipitate immediately formed. The mixture was allowed to cool to room temperature with vigorous stirring and the orange yellow solid filtered off washed with dioxan and ether and finally with a little cold ethanol to give DL-1-benzhydrylaminoethane phosphonous acid, melting point 220°-221°.

Aufarbeitung

  1. temperatureThe mixture was then heated slowly to 50° when solution
  2. customa flocculent precipitate immediately formed
  3. stirringwith vigorous stirring
  4. filtrationthe orange yellow solid filtered off
  5. washwashed with dioxan and ether and finally with a little cold ethanol

Quellen und Nachweise

ORD-Eintrag
ord-c36872adac9c4d889b5e07045c57da1c
Quelldatensatz
uspto-grants-1979_04
Patentnummer
US04147780

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