Ammonia → 2-Amino-5-fluorobenzoic acid

HRID 259920

Reaktionsgleichung

Reaktionsgleichung von HRID 259920
[Na].[F:2][C:3]1[CH:4]=[CH:5][C:6](Br)=[C:7]([CH:11]=1)[C:8]([OH:10])=[O:9].[K].[NH3:14]>[OH-].[K+]>[F:2][C:3]1[CH:11]=[C:7]([C:8]([OH:10])=[O:9])[C:6]([NH2:14])=[CH:5][CH:4]=1

Komponenten

6

Edukt 4

HCID 222AmmoniaHCID 27781812-Bromo-5-fluorobenzoic acid2×HCID 5360545SodiumHCID 5462222Potassium

Produkt 1

HCID 1014122-Amino-5-fluorobenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14797Potassium HydroxideLösungsmittel

Versuchsvorschrift

If the sodium salt solution of 5-fluoro-2-bromobenzoic acid is replaced by aliquot parts of the potassium or ammonium salt solution, prepared by dissolving 219 parts of 5-fluoro-2-bromobenzoic acid in 256.1 parts of 21.9% strength aqueous potassium hydroxide or, respectively, 217 parts of 7.9% aqueous ammonia solution and used as the metering medium in a procedure otherwise identical to that indicated, then 5-fluoroanthranilic acid is obtained in identical yield and quality.

Aufarbeitung

  1. customprepared

Quellen und Nachweise

ORD-Eintrag
ord-4f2f20decea5457bb0487fd375f40d1a
Quelldatensatz
uspto-grants-1996_06
Patentnummer
US05523472

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