Ammonia → 2-Amino-5-fluorobenzoic acid

HRID 259921

Reaktionsgleichung

Reaktionsgleichung von HRID 259921
[NH3:1].[F:2][C:3]1[CH:4]=[CH:5][C:6](Br)=[C:7]([CH:11]=1)[C:8]([O-:10])=[O:9]>Cl[Cu]>[F:2][C:3]1[CH:11]=[C:7]([C:8]([OH:10])=[O:9])[C:6]([NH2:1])=[CH:5][CH:4]=1

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 70155575-Fluoro-2-bromobenzoate

Produkt 1

HCID 1014122-Amino-5-fluorobenzoic acidAusbeute 85,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 62652Cuprous chlorideKatalysator

Versuchsvorschrift

Example 9 is repeated precisely, the only difference being that one part of CuCl is added to the initial ammonia solution charge. After the 5-fluoro-2-bromobenzoate solution has been metered in and the batch worked up, 144 parts of 5-fluoroanthranilic acid of m.p. 176.5°-177.5° C. are obtained with a purity of 91.9% (HPLC), corresponding to a yield of 85.4% of theory, based on the 5-fluoro-2-bromobenzoic acid employed.

Aufarbeitung

  1. additioncharge

Quellen und Nachweise

ORD-Eintrag
ord-0d5c3bb66e8b4bc8b7db9d2987871fc0
Quelldatensatz
uspto-grants-1996_06
Patentnummer
US05523472

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