o-Vanillin → Benzaldehyde, 3-methoxy-2-(4-nitrophenoxy)-

HRID 260071

Reaktionsgleichung

Reaktionsgleichung von HRID 260071
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[O:11]=[CH:12][C:13]1[CH:21]=[CH:20][CH:19]=[C:16]([O:17][CH3:18])[C:14]=1[OH:15].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:18][O:17][C:16]1[C:14]([O:15][C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=2)=[C:13]([CH:21]=[CH:20][CH:19]=1)[CH:12]=[O:11]

Komponenten

5

Edukt 3

HCID 8991o-VanillinHCID 9590p-FluoronitrobenzeneHCID 11430Potassium Carbonate

Produkt 1

HCID 22402430Benzaldehyde, 3-methoxy-2-(4-nitrophenoxy)-Ausbeute 71 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 14.10 g (0.10 mole) of 4-fluoronitrobenzene, 16.40 g (0.10 mole) of o-vanillin, 30 g of powdered potassium carbonate, and 40 mL of DMF is heated with stirring to the boiling point. After 10 minutes the mixture is cooled to 100° C. and 300 mL of ice water is added. Petroleum ether (200 mL) is added and the entire mixture is filtered and the cake is washed with 200 mL of water and then 200 mL of petroleum ether. The damp cake is slurried in 100 mL of methanol and filtered; wt 19.50 g (71% yield); mp 130°-131° C.; mass spectrum (DEI), 273 (M+).

Aufarbeitung

  1. temperatureis heated
  2. filtrationthe entire mixture is filtered
  3. washthe cake is washed with 200 mL of water
  4. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-a182eebdcb214c58be24a004df17ef86
Quelldatensatz
uspto-grants-1996_06
Patentnummer
US05525614

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