Valproic Acid → 2-Propylvaleryl chloride

HRID 260201

Reaktionsgleichung

Reaktionsgleichung von HRID 260201
[C:1]([OH:10])(=O)[CH:2]([CH2:6][CH2:7][CH3:8])[CH2:3][CH2:4][CH3:5].S(Cl)([Cl:13])=O>C1C=CC=CC=1>[C:1]([Cl:13])(=[O:10])[CH:2]([CH2:6][CH2:7][CH3:8])[CH2:3][CH2:4][CH3:5]

Komponenten

4

Edukt 2

HCID 3121Valproic AcidHCID 24386Thionyl Chloride

Produkt 1

HCID 762402-Propylvaleryl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

To 4.32 g (30 mmol) of valproic acid in an ice bath, thionyl chloride (3.60 g, 30 mmol) was slowly added, with stirring. The neat mixture was allowed to come to room temperature and then heated in a water bath at 50° C. for 30 minutes. 50 M1 portions of dry benzene were twice added and removed under reduced pressure. The resultant product was used in subsequent reactions without further purification.

Aufarbeitung

  1. customto come to room temperature
  2. customremoved under reduced pressure
  3. customThe resultant product was used in subsequent reactions without further purification

Quellen und Nachweise

ORD-Eintrag
ord-7062ea72074043e7bf4ec57d183adc6d
Quelldatensatz
uspto-grants-1996_06
Patentnummer
US05525727

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