Hydrochloric Acid → Ethyl 5-chloro-3-phenylsulfonylindole-2-carboximidate

HRID 260495Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 260495
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]#[N:12])=[C:5]2[S:13]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)(=[O:15])=[O:14].Cl.[CH2:23]([OH:25])[CH3:24]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11](=[NH:12])[O:25][CH2:23][CH3:24])=[C:5]2[S:13]([C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)(=[O:15])=[O:14]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 224015145-chloro-3-(phenylsulfonyl)-1H-Indole-2-carbonitrile

Produkt 1

HCID 135761968Ethyl 5-chloro-3-phenylsulfonylindole-2-carboximidate

Versuchsvorschrift

5-Chloro-3-phenylsulfonylindole-2-carbonitrile is allowed to react with ethanol saturated with hydrogen chloride at 0°-10° C. for 7 days. Evaporation to dryness affords the title compound as a hydrochloride salt. The title compound is obtained as a free base by adding the reaction mixture to an ice cold solution of excess potassium carbonate and extracting the product with chloroform.

Aufarbeitung

  1. customEvaporation to dryness

Quellen und Nachweise

ORD-Eintrag
ord-b5ca2beacb904c069c533ceac9550f73
Quelldatensatz
uspto-grants-1996_06
Patentnummer
US05527819

Notizen zur Reaktion

Wird geladen…