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7H-Naphtho(1,2,3-ij)(2,7)naphthyridin-7-one → 4-Bromosampangine

HRID 260760
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C1C=CC2[C:17](=[O:18])[C:16]3C4C(C=CN=3)=CC=NC=4C=2C=1.[Br:19][C:20]1[C:29]2[C:24]3=[C:25]([C:30]4[C:35]([C:36](=[O:37])[C:23]3=[N:22][CH:21]=1)=[CH:34][CH:33]=[CH:32][CH:31]=4)[N:26]=[CH:27][CH:28]=2.C1C=C[NH+]=CC=1.Br[Br-]Br>C(Cl)(Cl)Cl>[CH:32]1[CH:31]=[C:30]2[C:25]3[C:24]4[C:23]([C:36](=[O:37])[C:35]2=[CH:34][CH:33]=1)=[N:22][CH:21]=[C:20]([Br:19])[C:29]=4[CH:28]=[CH:27][N:26]=3.[CH3:16][CH2:17][O:18][C:21]1[N:22]=[C:23]2[C:24]3[C:25]([C:30]4[C:35]([C:36]2=[O:37])=[CH:34][CH:33]=[CH:32][CH:31]=4)=[N:26][CH:27]=[CH:28][C:29]=3[C:20]=1[Br:19]
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Komponenten

5

Edukt 2

HCID 3871957H-Naphtho(1,2,3-ij)(2,7)naphthyridin-7-one2×HCID 99048014-Bromosampangine

Produkt 2

HCID 99048014-BromosampangineAusbeute 64 %HCID 103161514-Bromo-5-ethoxysampangineAusbeute 1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

Electrophilic Bromination of Sampangine: Preparation of 4-Bromo-7H-naphtho[1,2,3-ij] [2,7]naphthyridin-7-one [4-Bromosampangine, 5] and 4-Bromo-5-ethoxy-7H-naphtho[1,2,3-ij][2,7]naphthyridin-7-one[4-Bromo-5-ethoxysampangine, 20]. A mixture of pyridinium bromide perbromide (4.80 g, 15.0 mmol) and sampangine (2.32 g, 10.0 mmol) in CHCl3 (100 mL) was heated at reflux for 24 h. After cooling, the mixture was poured into a separatory funnel and washed with saturated aqueous NaHCO3Solution (2×250 mL). The organic layer was dried (K2CO3) and concentrated to dryness. The residual solids were subjected to flash silica gel chromatography while eluting with CHCl3 to give pure 4-bromosampangine (5) (2.00 g, 64%) and 4-bromo-5-ethoxysampangine (20) (0.05 g, 1%). An analytical sample of 20 was obtained by crystallization from CHCl3. Compound 5: mp 244°-246° C.; IR (KBr) 1670, 1590, 1400, 1320, 1310, 1275, 1230, 980, 790, 755, 720 cm-1 ; 1H NMR (CDCl3) δ7.72 (ddd, 1 H, J=7.9, 7.9, 1.4 Hz), 7.86 (ddd, 1 H, J=7.9, 7.9, 1.4 Hz), 7.96 (d, 1 H, J=5.9 Hz), 8.46 (dd, 1 H, J=7.9, 1.4 Hz), 8.85 (dd, 1 H, J=7.9, 1.4 Hz), 8.99 (d, 1 H, J=5.9 Hz), 9.28 (s, 1H); 13C NMR (CDCl3) 118.3 (1), 120.5 (0), 123.7 (0), 125.8 (1), 128.7 (1), 131.8 (1), 132.3 (0), 135.0 (1), 135.1 (0), 138.6 (0), 146.7 (0), 148.6 (1), 150.2 (1), 151.7 (0), 181.6 (0) ppm; Anal. (exact mass, HREIMS) calcd for C15H7BrN2O m/e 309.9741, found 309.9747; Anal. calcd for C15H7BrN2O: C 57.90, H 2.27, N 9.00; found C 57.70, H 2.27, N 9.26. Compound 20: mp 200°-201° C.; IR (KBr) 1670, 1592, 1570, 1430, 1382, 1365, 1330, 1270, 1212, 1080, 1070, 1042, 980, 845, 762, 755, 720, 710, 635 cm-1 ; 1H NMR (CDCl3) δ1.56 (t, 3 H, J=7.1 Hz), 4.79 (q, 2 H, J=7.1 Hz), 7.67 (ddd, 1 H, J=7.3, 7.3, 1.4 Hz), 7.79 (ddd, 1 H, J=7.3, 7.3, 1.4, Hz), 7.82 (d, 1 H, J=6.1 Hz), 8.36 (dd, 1 H, J=7.3, 1.4 Hz), 8.72 (d, 1 H, J=6.1 Hz), 8.75 (dd, 1 H, J=7.3, 1.4 Hz); 13C NMR (CDCl3) 14.6 (3), 64.7 (2), 107.4 (0), 117.5 (0), 117.8 (1), 125.5 (1), 128.2 (1), 131.4 (1), 132.2 (0), 134.5 (1), 135.0 (0), 140.9 (0), 144.6 (0), 147.2 (1), 151.7 (0), 159.9 (0), 181.4 (0) ppm; Anal. calcd for C17H11BrN2O: C 57.48, H 3.12, N 7.88; found C 57.09, H 3.37, N 7.75.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 24 h
  3. temperatureAfter cooling
  4. additionthe mixture was poured into a separatory funnel
  5. washwashed with saturated aqueous NaHCO3Solution (2×250 mL)
  6. dry with materialThe organic layer was dried (K2CO3)
  7. concentrationconcentrated to dryness
  8. washwhile eluting with CHCl3

Quellen und Nachweise

ORD-Eintrag
ord-c5efb14e929b4f609a85a7b8bd558e71
Quelldatensatz
uspto-grants-1996_06
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US05530004

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