2,6-Dichloropyrazine → 4-(6-Chloropyrazin-2-yl)piperazin-2-one

HRID 261060Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 261060
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[O:9]=[C:10]1[CH2:15][NH:14][CH2:13][CH2:12][NH:11]1>C(#N)C>[Cl:8][C:4]1[N:3]=[C:2]([N:14]2[CH2:13][CH2:12][NH:11][C:10](=[O:9])[CH2:15]2)[CH:7]=[N:6][CH:5]=1

Komponenten

4

Edukt 2

HCID 785042,6-DichloropyrazineHCID 231360Piperazin-2-one

Produkt 1

HCID 203960024-(6-Chloropyrazin-2-yl)piperazin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A mixture of 10.0 g (0.0067 mole) of 2,6-dichloropyrazine and 14 g (0.14 mole) of 2-oxopiperazine in 100 ml of acetonitrile is refluxed 1.5 hour with stirring under N2. The mixture is concentrated under vacuum, the residue titrated with water and filtered, and the crude solid recrystallized from water (charcoal treatment) to give off-white plates of the subject compound, 7.7 g, mp 192°-193° C.

Aufarbeitung

  1. temperatureis refluxed 1.5 hour
  2. concentrationThe mixture is concentrated under vacuum
  3. filtrationfiltered
  4. customthe crude solid recrystallized from water (charcoal treatment)
  5. customto give off-white plates of the subject compound, 7.7 g, mp 192°-193° C.

Quellen und Nachweise

ORD-Eintrag
ord-fbaa38e21c5b4138988186de4e3cf619
Quelldatensatz
uspto-grants-1979_08
Patentnummer
US04163849

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