Methyl iodide → 3,5-diamino-1-methyl-1H-pyrazole-4-carbonitrile

HRID 261072Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 261072
[NH2:1][C:2]1[C:6]([C:7]#[N:8])=[C:5]([NH2:9])[NH:4][N:3]=1.IC.[C:12](=O)([O-])[O-].[K+].[K+]>CC(C)=O>[NH2:1][C:2]1[C:6]([C:7]#[N:8])=[C:5]([NH2:9])[N:4]([CH3:12])[N:3]=1

Komponenten

5

Edukt 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 142021413,5-Diamino-1H-pyrazole-4-carbonitrile

Produkt 1

HCID 126210283,5-diamino-1-methyl-1H-pyrazole-4-carbonitrileAusbeute 16,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

3,5-Diamino-4-cyanopyrazole (6.1 g) prepared as in Example 3, iodomethane (3.1 ml), anhydrous potassium carbonate (7.6 g) and acetone (120 ml) were heated under reflux for 18 hours. The mixture was filtered, and the filtrate was concentrated to a viscous oil. Trituration of the oil with water gave a precipitate of 3,5-diamino-4-cyano-1-methylpyrazole (1.1 g), m.p. 194°-196° C.

Aufarbeitung

  1. temperaturewere heated
  2. temperatureunder reflux for 18 hours
  3. filtrationThe mixture was filtered
  4. concentrationthe filtrate was concentrated to a viscous oil

Quellen und Nachweise

ORD-Eintrag
ord-027954cc5b4a46fdabac1c15a9c3705b
Quelldatensatz
uspto-grants-1979_08
Patentnummer
US04163846

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