Propanedinitrile, 2-[(methylamino)(methylthio)methylene]- → HCID 178484952, Verbindung

HRID 261432

Reaktionsgleichung

Reaktionsgleichung von HRID 261432
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][CH2:13][NH2:14])[N:9]=1)[C:2]([NH2:4])=[NH:3].[C:15]([C:17]([C:23]#[N:24])=[C:18]([NH:21][CH3:22])SC)#[N:16]>C(#N)C>[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:18]([NH:21][CH3:22])=[C:17]([C:23]#[N:24])[C:15]#[N:16])[N:9]=1)[C:2]([NH2:4])=[NH:3]

Komponenten

4

Edukt 2

HCID 3640288Propanedinitrile, 2-[(methylamino)(methylthio)methylene]-HCID 178512644HCID 178512644, Verbindung

Produkt 1

HCID 178484952HCID 178484952, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A mixture of 2-guanidino-4-(4-aminobutyl)thiazole (0.43 g.) and 1,1-dicyano-2-methylamino-2-methylthioethylene (0.3 g.) in acetonitrile (10 ml.) was heated under reflux for 16 hours. The mixture was then evaporated to dryness and the resulting gum purified by chromatography on a silica column using chloroform/methanol/ammonia (s.g. 0.880) 80:20:0.5 v/v/v as developing solvent to give 1-[4-(2-guanidinothiazol-4-yl)butylamino]-1-methylamino-2,2-dicyanoethylene.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 16 hours
  3. customThe mixture was then evaporated to dryness
  4. customthe resulting gum purified by chromatography on a silica column

Quellen und Nachweise

ORD-Eintrag
ord-88ba70d0e2dc45659838c5342cf3cd01
Quelldatensatz
uspto-grants-1979_08
Patentnummer
US04165377

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