4-Fluoroiodobenzene → 4-Acetyl-4'-fluoro-2-nitrobiphenyl

HRID 262323

Reaktionsgleichung

Reaktionsgleichung von HRID 262323
[F:1][C:2]1[CH:7]=[CH:6][C:5](I)=[CH:4][CH:3]=1.[CH3:9][C:10]([C:12]1[CH:17]=[CH:16][C:15](Br)=[C:14]([N+:19]([O-:21])=[O:20])[CH:13]=1)=[O:11]>CO>[C:10]([C:12]1[CH:17]=[CH:16][C:15]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)=[C:14]([N+:19]([O-:21])=[O:20])[CH:13]=1)(=[O:11])[CH3:9]

Komponenten

4

Edukt 2

HCID 96054-FluoroiodobenzeneHCID 877371-(4-Bromo-3-nitrophenyl)ethan-1-one

Produkt 1

HCID 213205554-Acetyl-4'-fluoro-2-nitrobiphenyl

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

4-fluoroiodobenzene and 4-bromo-3-nitroacetophenone were reacted under Ullmann conditions to give 4-acetyl-4'-fluoro-2-nitrobiphenyl, m.p. 88°-90° C. (from methanol). This compound was reduced with stannous chloride in concentrated hydrochloric acid to give 4-acetyl-2-amino-4'-fluorobiphenyl, m.p. 88°-91° C. (from methanol). The amino group in this compound was converted to methoxy in the following way:

Quellen und Nachweise

ORD-Eintrag
ord-04f76ec2a7f6441cb011856833208acf
Quelldatensatz
uspto-grants-1979_05
Patentnummer
US04153807

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