4-(((2-Aminoethyl)thio)methyl)-5-methylimidazole → 2-[2-(5-Methyl-4-imidazolylmethylthio)ethylamino]-5-(4-pyridylmethyl)-4-pyrimidone

HRID 262494Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 262494
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]2[C:9](=[O:16])[NH:10][C:11](SC)=[N:12][CH:13]=2)=[CH:3][CH:2]=1.[CH3:17][C:18]1[NH:22][CH:21]=[N:20][C:19]=1[CH2:23][S:24][CH2:25][CH2:26][NH2:27]>>[CH3:17][C:18]1[NH:22][CH:21]=[N:20][C:19]=1[CH2:23][S:24][CH2:25][CH2:26][NH:27][C:11]1[NH:10][C:9](=[O:16])[C:8]([CH2:7][C:4]2[CH:3]=[CH:2][N:1]=[CH:6][CH:5]=2)=[CH:13][N:12]=1

Komponenten

3

Edukt 2

HCID 6655684-(((2-Aminoethyl)thio)methyl)-5-methylimidazoleHCID 143385852-(Methylthio)-5-(pyridin-4-ylmethyl)pyrimidin-4(1H)-one

Produkt 1

HCID 30489042-[2-(5-Methyl-4-imidazolylmethylthio)ethylamino]-5-(4-pyridylmethyl)-4-pyrimidone

Versuchsvorschrift

An intimate mixture of 5-(4-pyridylmethyl)-2-methylthio-4-pyrimidone (5.9 g) and 2-(5-methyl-4-imidazolylmethylthio)ethylamine (4.3 g) was heated at 145°-150° for 5 hours and allowed to cool to give 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(4-pyridylmethyl)-4-pyrimidone. This residue was triturated with water, and treated with ethanolic hydrogen chloride to give the title compound m.p. 228°-233°.

Aufarbeitung

  1. temperaturewas heated at 145°-150° for 5 hours
  2. temperatureto cool

Quellen und Nachweise

ORD-Eintrag
ord-8edd892368b64f5998e2b346f28b98f9
Quelldatensatz
uspto-grants-1979_05
Patentnummer
US04154834

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