Ethyl isothiocyanate → N-ethyl-N'-[2-(2-pyrazinylmethylamino)ethyl]thiourea

HRID 262637

Reaktionsgleichung

[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[CH2:7][NH:8][CH2:9][CH2:10][NH2:11].[CH2:12]([N:14]=[C:15]=[S:16])[CH3:13]>>[CH2:12]([NH:14][C:15]([NH:11][CH2:10][CH2:9][NH:8][CH2:7][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][N:1]=1)=[S:16])[CH3:13]

Komponenten

Edukt 2

HCID 10966Ethyl isothiocyanate

HCID 13910894N-(pyrazinylmethyl)ethylenediamine

Produkt 1

HCID 20567640N-ethyl-N'-[2-(2-pyrazinylmethylamino)ethyl]thiourea

Versuchsvorschrift

Reacting N-(2-pyrazinylmethyl)ethylenediamine with ethyl isothiocyanate by the procedure of Example 3 and chromatographing gives N-ethyl-N'-[2-(2-pyrazinylmethylamino)ethyl]thiourea. Reacting this thiourea with lead cyanamide by the procedure of Example 3 gives N-cyano-N'-ethyl-N"-[2-(2-pyrazinylmethylamino)ethyl]-guanidine.

Quellen und Nachweise

ORD-Eintrag: ord-20b3c5232b844542baa4cae791ce9a55
Quelldatensatz: uspto-grants-1979_05
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04154844

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