Toluene → 3-(3-Fluoro-4-isopropyl-phenyl)-5-methyltetrahydro-1,3,5-oxadiazin-4-one

HRID 262931

Reaktionsgleichung

[F:1][C:2]1[CH:3]=[C:4]([NH:11][C:12]([NH:14][CH3:15])=[O:13])[CH:5]=[CH:6][C:7]=1[CH:8]([CH3:10])[CH3:9].CN(C)[CH:18]=[O:19].[C:21]1(C)C=CC=CC=1>C1(C)C=CC(S(O)(=O)=O)=CC=1>[F:1][C:2]1[CH:3]=[C:4]([N:11]2[C:12](=[O:13])[N:14]([CH3:21])[CH2:15][O:19][CH2:18]2)[CH:5]=[CH:6][C:7]=1[CH:8]([CH3:9])[CH3:10]

Komponenten

Reaktionsbedingungen

Temperatur: 80 °C

Versuchsvorschrift

N-(3-Fluoro-4-isopropyl-phenyl)-N'-methyl-urea (one mol=210 g.) and polyoxymethylene (1 mol=90 g.) are dissolved in toluene (800 cc.) in the presence of para-toluenesulphonic acid (0.3 mol=51.6 g.) as a catalyst and of dimethylformamide (0.3 mol=22 g.), and the mixture is heated for 15 minutes at 80° C. After having washed the solution with water and then concentrated it, 3-(3-fluoro-4-isopropyl-phenyl)-5-methyltetrahydro-1,3,5-oxadiazin-4-one is obtained in the form of an oil which is purified by dissolving in hot hexane and recrystallising.

Aufarbeitung

washAfter having washed the solution with water
concentrationconcentrated it

Quellen und Nachweise

ORD-Eintrag: ord-510a4bf1a90642f583f7a61a6c0b2b29
Quelldatensatz: uspto-grants-1979_05
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04155747

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