Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Water | HCID 962 | — |
| Edukt | Chloroform | HCID 6212 | — |
| Edukt | Ethyl 2-bromovalerate | HCID 79071 | — |
| Edukt | Phthalimide potassium salt | HCID 24194345 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | Ethyl alpha-phthalimidopentanoate | HCID 13791337 | — |
Reaktionsschritte
To a solution of potassium phthalimide (0.1 mole) in about 50 ml of dimethylformamide (DMF) is added 1 equivalent of ethyl-2-bromopentanoate. The temperature is maintained at about 60° C. for 10 minutes. Chloroform is added to the cooled DMF solution and the mixture is poured into water. The phases are separated and the aqueous phase is extracted with chloroform. The chloroform extracts are combined, extracted with 0.1 N sodium hydroxide and with water. After drying over sodium sulfate, the chloroform is removed to give ethyl α-phthalimidopentanoate.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US04148998 |
|---|
| Quelldatensatz | uspto-grants-1979_04 |
|---|
| ORD ID | ord-238e2c7868bf4c0ab667f4ccfcc35579 |
|---|
| Quellennotiz | uspto-grants-1979_04 |
|---|
