Ammonia → 2-(4-Chloro-3-sulfamoylbenzoyl)-benzo[b]furan
Reaktionsgleichung
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[O:12][C:11]3[CH:13]=[CH:14][CH:15]=[CH:16][C:10]=3[CH:9]=2)=[O:7])=[CH:4][C:3]=1[S:19](Cl)(=[O:21])=[O:20].[NH3:23]>>[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[O:12][C:11]3[CH:13]=[CH:14][CH:15]=[CH:16][C:10]=3[CH:9]=2)=[O:7])=[CH:4][C:3]=1[S:19](=[O:21])(=[O:20])[NH2:23]Komponenten
3
Versuchsvorschrift
3.3 g 2-(4-Chloro-3-chlorosulfonylbenzoyl)-benzo[b]furan are introduced into 19 ml 25% aqueous ammonia solution, and after standing overnight, the liquid is distilled off. After addition of water, the pH is adjusted to 6 by means of dilute HCl, agitation is continued for a further 30 minutes, and the product is crystallized from a small amount of glacial acetic acid. Colorless crystals, m.p. 181° C.
Aufarbeitung
- distillationthe liquid is distilled off
- additionAfter addition of water
- waitis continued for a further 30 minutes
- customthe product is crystallized from a small amount of glacial acetic acid